Huiyong Yin Lab

Professor Huiyong YIN is currently a tenured Professor of Biomedical Sciences in Metabolism and Metabolic Diseases in the Department of Biomedical Sciences, and Associate Dean (Research) for Jockey Club College of Veterinary Medicine and Life Sciences. He is also a member of the State Key Laboratory of Marine Pollution at City University of Hong Kong (https://www.cityu.edu.hk/sklmp/). Before joining City University of Hong Kong in February 2023, Prof. Yin was a Senior Principal Investigator and Group Leader of Lipid Metabolism in Human Nutrition-related Diseases at Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), Shanghai, China. He was also the Distinguished Adjunct Professor in the School of Life Sciences and Technology in ShanghaiTech University since 2013. He obtained his BSc from Tongji University and MSc from Shanghai Institute of Organic Chemistry (SIOC), CAS, and PhD in Chemistry from Vanderbilt University in 2002. In 2003, Prof. Yin joined Vanderbilt University School of Medicine as a Research Instructor in the Division of Clinical Pharmacology, and was promoted to a Research Assistant Professor in 2005 and Associate Professor in 2008 in the Departments of Pharmacology, Medicine, and Chemistry. He also served as the Director for the Core Laboratory of Drug Metabolism and Pharmacokinetics (DMPK) in the drug discovery program at Vanderbilt University from 2007-2009. In August 2011, Prof. YIN was recruited back to the Institute of Nutritional Sciences (INS), Shanghai Institutes of Biological Sciences (SIBS), CAS, under the global talent recruitment program by Shanghai Municipal Government and CAS. He was the founding director of the Mass Spectrometry Facility for Nutrition and Food Safety at INS, SIBS from 2011 to 2017.

Professor Yin is one of the leading scientists in the field of redox regulation of glucose and lipid metabolism in human metabolic diseases. His research interest has been focusing on the understanding of metabolic reprogramming in carbohydrate and lipid metabolism in metabolic diseases including atherosclerosis, liver cancer, hyperuricemia and gout. For the past 20 years, Prof. Yin has made significant contributions in understanding the roles and underlying mechanisms of free radical lipid peroxidation in human diseases including atherosclerosis using the state-of-the art metabolomics/lipidomics approaches (Yin et al JACS, 2000; 2002; Yin et al Chem. Rev. 2011; Zhong et al, Redox Biol. 2015; Zhong et al, Free Radic. Biol. Med. 2019; Shen et al, Clin. Transl. Med., 2024), and discovered novel non-enzymatic functions of Aldehyde Dehydrogenase 2 (ALDH2) in cardiovascular disease (CVD) (Zhong et al, J. Clin. Invest. 2019; Li et al, JCI Insight, 2021; Zhong et al, Redox Biol. 2021; Zhang et al, Nat. Rev. Cardiol. 2023). His research for the past several years has defined novel pathways in metabolic reprogramming in liver cancer mediated by a key glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB) (Li et al, Nature Cancer, 2020; He et al, PLoS Biol., 2020; Liu et al, Hepatology, 2021; Yin et al, Hepatology, 2023). Using a precision medicine approach based on metabolomics and machine learning algorithms, Prof. Yin and his collaborators have established prediction models in assessing risks for gout attacks in asymptomatic hyperuricemia patients and the frequencies for gout flares (Shen et al, Arthritis. Rheumatol., 2021; Wang et al, Arthritis. Rheumatol., 2023; Lu et al, Nat. Rev. Rheumatol., 2019; Liang et al, Life Metab., 2024). Since 2000, Prof. Yin has co-authored around 170 peer-reviewed manuscripts in SCI-indexed journals including Science, Nature, Cell Metabolism, Nature Cancer, Nature Metabolism, Nature Review Cardiology, Nature Reviews Rheumatology, Molecular Cell, Journal of American Chemical Society, Hepatology, Redox Biology, Arthritis & Rheumatology, Free Radical Biology and Medicine, Journal of Biological Chemistry, Journal of Clinical Endocrinology and Metabolism, and Journal of American Society for Mass Spectrometry with > 15,300 Google Scholar citations and h-index of 67 (as of December 2024).  Prof. Yin has been listed as the top 2% of the Most-Cited Scientists by Stanford University since 2021 and was awarded prestigious “Senior International Scientists” in 2021 by National Natural Science Fund of China.